{"id":2679,"date":"2018-05-13T16:21:22","date_gmt":"2018-05-13T15:21:22","guid":{"rendered":"http:\/\/ocduk.net\/?page_id=2679"},"modified":"2025-09-26T13:23:14","modified_gmt":"2025-09-26T12:23:14","slug":"medication","status":"publish","type":"page","link":"https:\/\/www.ocduk.org\/overcoming-ocd\/medication\/","title":{"rendered":"Medication for OCD"},"content":{"rendered":"<p><a href=\"\/wp-content\/uploads\/2018\/05\/SSRI.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-2743\" src=\"\/wp-content\/uploads\/2018\/05\/SSRI-1024x652.jpeg\" alt=\"3D illustration of &quot;SSRI&quot; title on pill bottle, isolated on white.\" width=\"500\" height=\"318\" srcset=\"https:\/\/www.ocduk.org\/wp-content\/uploads\/2018\/05\/SSRI-1024x652.jpeg 1024w, https:\/\/www.ocduk.org\/wp-content\/uploads\/2018\/05\/SSRI-300x191.jpeg 300w, https:\/\/www.ocduk.org\/wp-content\/uploads\/2018\/05\/SSRI-768x489.jpeg 768w, https:\/\/www.ocduk.org\/wp-content\/uploads\/2018\/05\/SSRI-100x64.jpeg 100w, https:\/\/www.ocduk.org\/wp-content\/uploads\/2018\/05\/SSRI-943x600.jpeg 943w, https:\/\/www.ocduk.org\/wp-content\/uploads\/2018\/05\/SSRI-1300x827.jpeg 1300w, https:\/\/www.ocduk.org\/wp-content\/uploads\/2018\/05\/SSRI-600x382.jpeg 600w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/a><\/p>\n<p>There are a number of treatments options for children and adults with Obsessive-Compulsive Disorder (OCD) that evidence shows can be helpful, including psychological therapies and medication.<\/p>\n<p>The primary treatment approach for most people will be to start with psychological treatment in the form of Cognitive Behavioural Therapy (CBT).\u00a0 However, for some people where therapy as not proved successful initially, the NICE guidelines recommend additional therapy (CBT with ERP), or a choice of medication in the form of <strong>Selective Serotonin Reuptake Inhibitors (SSRI).<\/strong><\/p>\n<p>Although medication is not recommended as an initial treatment method for most people with OCD, in the past many people were offered medication whilst on long waiting lists for psychological therapy.\u00a0 If this happens, it should be your choice whether to try medication or not.<\/p>\n<p>Your healthcare professional should discuss all your treatment options with you so you can decide if you want to have a particular treatment or not, and which treatment you might prefer. Your own preference is important and after a full discussion your healthcare professional should support your choice where possible.<\/p>\n<p>Whilst some people may be anxious about taking medication, the medication could be helpful in dealing with the OCD and\/or with the reduction of anxiety and improvement on low feelings enough to make it easier to start, and eventually succeed, in therapy.<\/p>\n<p>&nbsp;<\/p>\n<h5>The types of Medications<\/h5>\n<p>The medication used for treating OCD usually take the form of antidepressants which act in the serotonin system, and are called <mark class=\"x-highlight\">Selective Serotonin Re-uptake Inhibitor<\/mark>, or <mark class=\"x-highlight\">SSRIs<\/mark> for short.<\/p>\n<div id=\"attachment_4249\" style=\"width: 310px\" class=\"wp-caption alignright\"><a href=\"\/wp-content\/uploads\/2018\/06\/med-spike.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-4249\" class=\"wp-image-4249 size-medium\" title=\"Some users have described it to us that the anxiety experienced by OCD can feel like a sharp spike, but after taking medication it makes that sharp spike become more of a rounded less sharp spike.\" src=\"\/wp-content\/uploads\/2018\/06\/med-spike-300x125.jpg\" alt=\"Image of two spikes, one sharp the other rounded\" width=\"300\" height=\"125\" srcset=\"https:\/\/www.ocduk.org\/wp-content\/uploads\/2018\/06\/med-spike-300x125.jpg 300w, https:\/\/www.ocduk.org\/wp-content\/uploads\/2018\/06\/med-spike-100x42.jpg 100w, https:\/\/www.ocduk.org\/wp-content\/uploads\/2018\/06\/med-spike-600x250.jpg 600w, https:\/\/www.ocduk.org\/wp-content\/uploads\/2018\/06\/med-spike.jpg 714w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><p id=\"caption-attachment-4249\" class=\"wp-caption-text\">SOME USERS HAVE DESCRIBED IT TO US THAT THE ANXIETY EXPERIENCED BY OCD CAN FEEL LIKE A SHARP SPIKE, BUT AFTER TAKING MEDICATION, THAT SHARP SPIKE BECOMES MORE OF A ROUNDED SPIKE.<\/p><\/div>\n<p>We do not know exactly why SSRIs are helpful for some people with OCD, it\u2019s thought they might have an effect by\u00a0altering the balance of chemicals in your brain, but what we do know is that they sometimes reduce the severity of obsessive-compulsive symptoms, by taking the \u2018edge\u2019 off some of the anxiety experienced.\u00a0 Some users have described it to us that the anxiety experienced by OCD can feel like a sharp spike, but after taking medication, that sharp spike becomes more of a rounded spike.<\/p>\n<h5>Medication types used to treat OCD:<\/h5>\n<p>Drugs often have several names. When a drug is first discovered it\u2019s given an approved\u00a0<strong>generic<\/strong>\u00a0name but since medicines are often made by different companies, they also have one or more\u00a0<strong>brand<\/strong>\u00a0(trading) names, making it very confusing.\u00a0 The brand name is often chosen to be memorable for advertising, or to be easier to say or spell than the generic name which can often be cumbersome. For example, the generic name for Prozac is Fluoxetine.\u00a0\u00a0Whilst the\u00a0brand name is usually written most clearly on any packaging, you will always see the generic name written somewhere on the packet or leaflet, although often in small print.<\/p>\n<p>Here in the UK there are strict quality controls before a product licence is granted for brand versions of medicines. This means that in theory a generic or brand name version of the same medicine will have the same action and be of the same quality. Although some users have told us that they have noticed a difference, for example in 2015 when Anafranil was discontinued, a handful of users struggled taking the generic version, Clomipramine.<\/p>\n<p>So with each drug recommended for the treatment of OCD we will list both the generic and brand name, if you are confused over medication names, please do discuss with your prescribing doctor.<\/p>\n<hr class=\"x-gap\" style=\"margin: 60px 0 0 0;\" \/>\n<p><strong>Selective Serotonin Reuptake Inhibitors (SSRI)<\/strong><br \/>\nSSRI medications are usually tried first (before non-selective SRIs) because SSRIs only act on serotonin. The SSRIs usually recommended for the treatment of OCD in the UK are:<\/p>\n<p><strong>Generic Name \/ (Brand Names)<\/strong><\/p>\n<ul>\n<li><a href=\"citalopram\">Citalopram<\/a> (Celexa, Cipramil)<\/li>\n<li><a href=\"escitalopram\">Escitalopram<\/a> (Cipralex, Lexapro)<\/li>\n<li><a href=\"fluoxetine\">Fluoxetine<\/a> (Prozac)<\/li>\n<li><a href=\"fluvoxamine\">Fluvoxamine<\/a> (Faverin, Luvox)<\/li>\n<li><a href=\"paroxetine\">Paroxetine<\/a> (Paxil, Seroxat)<\/li>\n<li><a href=\"sertraline\">Sertraline<\/a> (Lustral, Zoloft)<\/li>\n<\/ul>\n<p>If these medications fail to work, a non-selective SRI may be prescribed. However, because it affects neurotransmitters in the brain other than just serotonin, there are more side effects and therefore it is usually not a first choice medication for treating OCD. The non-selective SRI most commonly used for treating OCD is:<\/p>\n<p><strong>Tricyclic Antidepressant (TCA)<\/strong><\/p>\n<ul>\n<li><a href=\"clomipramine\">Clomipramine<\/a> (Anafranil)<\/li>\n<\/ul>\n<p>The <a href=\"\/nice-guidelines-for-the-treatment-of-ocd\/\">NICE guidelines<\/a>\u00a0 state:<\/p>\n<p class=\"indent\">Clomipramine should be considered in the treatment of adults with OCD or BDD after an adequate trial of at least one SSRI has been ineffective or poorly tolerated, or if the patient prefers Clomipramine or\u00a0has had success in using the medication before.<\/p>\n<p>Typically, the process of determining the most suited medication for an individual is achieved on a trial-and-error basis. However, in order to allow its maximum effects to be adequately observed, each medication should be taken for a specified time period, usually for at least 12-16 weeks, before seeking out an alternative, but always discuss with your prescribing doctor before making any changes to your dosage or type of medication.<\/p>\n<p>This is not an exhaustive list, and sufferers may often be prescribed additional medications to enhance or augment the effects of these SSRIs. For example, part of the criteria to access some of the NHS national treatment clinics is augmentation of medication, which could include anti-psychotic medications alongside SSRI. Although the efficacy of anti-psychotics for the treatment of OCD is open to debate with some research suggesting it&#8217;s no more effective than placebo.<\/p>\n<p class=\"indent\">\n<hr class=\"x-gap\" style=\"margin: 60px 0 0 0;\" \/>\n<p><strong>Medication for Children<\/strong><br \/>\nFor children, the NICE Guidelines for the treatment of OCD suggested that two of the SSRI&#8217;s listed had a UK marketing authorisation for treating OCD in children. Those were:<\/p>\n<ul>\n<li>Fluvoxamine (8 years and older)<\/li>\n<li>Sertraline (6 years and older)<\/li>\n<\/ul>\n<p>Although in practice other medications may be prescribed to children, it\u2019s worth pointing out that the NICE Guidelines were published in 2005, so knowledge around using SSRIs for children with OCD will have come on since publication. If a child is prescribed another drug to those listed above, it\u2019s worth asking the prescribing doctor why\u00a0 an alternative medication is being prescribed to their child instead of one of the above two medications.<\/p>\n<h5>Medication and side effects<\/h5>\n<p>All medications have the potential for side effects, but that does not mean every person will suffer with side effects.\u00a0 We all have different bodies and tolerances to medications, so 10 people could be offered the exact same type, brand and dosage of medication and results will vary from the negative (making them feel worse) through a range of side effects to the positive results without any side effects at all.\u00a0 So it is important you ask a prescribing doctor to discuss the potential side effects with you, Of course the reality is, until you start taking any medication you won\u2019t know if you will have any side effects at all.\u00a0 Click here to read more about potential <a title=\"Learn more about medication side effects\" href=\"\/overcoming-ocd\/medication\/medication-side-effects\/\">side effects<\/a>.<\/p>\n<h5>Coming off Medications<\/h5>\n<p>Although someone on medication may stop taking SSRIs whenever they wish, we always recommend that they\u2019re reduced gradually under supervision from their prescribing doctor.<\/p>\n<p>It\u2019s also worth pointing out that NICE recommend, that if the medication has helped a person, they should continue taking the medication for at least 12 months to ensure their symptoms continue to improve and to prevent relapses.<\/p>\n<p>&nbsp;<\/p>\n<p class=\"titleh5\">What to read next:<\/p>\n<div class=\"x-column x-sm x-1-2\"><span class=\"alignleft\"> <a style=\"outline: none;\" title=\"Back to Other Therapies\" href=\"..\/other-therapies\/\"><i class=\"x-icon x-icon-arrow-left\" data-x-icon=\"\uf060\" aria-hidden=\"true\"><\/i> Other Therapies<\/a><\/span><\/div>\n<div class=\"x-column x-sm x-1-2 last\"><span class=\"alignright\"><a title=\"How SSRIs work\" href=\"..\/medication\/how-ssri-work\/\">How SSRIs work <i class=\"x-icon x-icon-arrow-right\" data-x-icon=\"\uf061\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\n<hr class=\"x-clear\" \/>\n<hr  class=\"x-gap\" style=\"margin: 20px 0 0 0;\">\n<div id=\"pi-accordion\" class=\"x-accordion\" > <div  class=\"x-accordion-group\" ><div class=\"x-accordion-heading\"><a id=\"tab-6940e19dceecc\" class=\"x-accordion-toggle collapsed\" role=\"tab\" data-x-toggle=\"collapse-b\" data-x-toggleable=\"6940e19dceecc\" data-x-toggle-group=\"pi-accordion\" aria-selected=\"false\" aria-expanded=\"false\" aria-controls=\"panel-6940e19dceecc\"><i class='x-framework-icon x-shortcode-accordion-icon' data-x-icon-s='&#x2b;' aria-hidden=true><\/i><span>Page information and additional reading<\/span><\/a><\/div><div id=\"panel-6940e19dceecc\" class=\"x-accordion-body x-collapsed\" role=\"tabpanel\" data-x-toggle-collapse=\"1\" data-x-toggleable=\"6940e19dceecc\" aria-hidden=\"true\" aria-labelledby=\"tab-6940e19dceecc\"><div class=\"x-accordion-inner\">\n<div  class=\"x-container max width\" >\n<div  class=\"x-column x-sm x-1-2\" style=\"\" >[lastreviewed]<\/div>\n<div  class=\"x-column x-sm x-1-2 last\" style=\"\" > [nextreviewed] <\/div>\n<\/div>\n<hr  class=\"x-gap\" style=\"margin: 20px 0 0 0;\">\n<p class=\"p-medium\"><b>Additional Reading:<\/b><\/p>\n<ul>\n<li>\n<p class=\"p-medium\"><a href=\"https:\/\/www.nhs.uk\/conditions\/ssri-antidepressants\/\" target=\"_blank\" rel=\"noopener\">NHS Choices &#8211; SSRI Medications <\/a><span class=\"p-small\">(External Website)<\/span><\/p>\n<\/li>\n<li>\n<p class=\"p-medium\"><a href=\"https:\/\/www.nhs.uk\/conditions\/antidepressants\/\/\" target=\"_blank\" rel=\"noopener\">NHS Choices &#8211; Antidepressants <\/a><span class=\"p-small\">(External Website)<\/span><\/p>\n<\/li>\n<li>\n<p class=\"p-medium\"><a href=\"https:\/\/www.nice.org.uk\/guidance\/CG31\" target=\"_blank\" rel=\"noopener\">NICE Guidelines for the treatment of OCD and BDD <\/a><span class=\"p-small\">(External Website)<\/span><\/p>\n<\/li>\n<li>\n<p class=\"p-medium\"><a href=\"https:\/\/bnf.nice.org.uk\/drug\/\" target=\"_blank\" rel=\"noopener\">NICE &#8211; Information about drugs <\/a><span class=\"p-small\">(External Website)<\/span><\/p>\n<\/li>\n<li>\n<p class=\"p-medium\"><a href=\"https:\/\/www.veale.co.uk\/news\/comment-on-risperidone-v-cbt-for-ocd-study\/\" target=\"_blank\" rel=\"noopener\">Dr David Veale blog &#8211; Comment on risperidone v CBT for OCD study <\/a><span class=\"p-small\">(External Website)<\/span><\/p>\n<\/li>\n<li>\n<p class=\"p-medium\">Research Paper: <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25432131\/\" target=\"_blank\" rel=\"noopener\">Atypical antipsychotic augmentation in SSRI treatment refractory obsessive-compulsive disorder: a systematic review and meta-analysis. <\/a><span class=\"p-small\">(External Website &#8211; Paywall)<\/span><\/p>\n<\/li>\n<\/ul>\n<hr  class=\"x-gap\" style=\"margin: 20px 0 0 0;\">\n<p class=\"p-small\"><b>Disclaimer:<\/b> This article is for information only and should not be used for the diagnosis or treatment of Obsessive-Compulsive Disorder or any other medical condition. OCD-UK have taken all reasonable care in compiling this information, but always recommend consulting a doctor or other suitably qualified health professional for diagnosis and treatment of Obsessive-Compulsive Disorder or any other medical condition.\n<\/div><\/div><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>There are a number of treatments options for children and adults with Obsessive-Compulsive Disorder (OCD) that evidence shows can be helpful, including psychological therapies and medication. The primary treatment approach for most people will be to start with psychological treatment &#8230; <\/p>\n<div><a href=\"https:\/\/www.ocduk.org\/overcoming-ocd\/medication\/\" class=\"more-link\">Read More<\/a><\/div>\n","protected":false},"author":1,"featured_media":0,"parent":2560,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2679","page","type-page","status-publish","hentry","no-post-thumbnail"],"_links":{"self":[{"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/pages\/2679","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/comments?post=2679"}],"version-history":[{"count":1,"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/pages\/2679\/revisions"}],"predecessor-version":[{"id":46906,"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/pages\/2679\/revisions\/46906"}],"up":[{"embeddable":true,"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/pages\/2560"}],"wp:attachment":[{"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/media?parent=2679"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}