{"id":2733,"date":"2018-05-13T20:02:41","date_gmt":"2018-05-13T19:02:41","guid":{"rendered":"http:\/\/ocduk.net\/?page_id=2733"},"modified":"2018-12-10T14:38:40","modified_gmt":"2018-12-10T14:38:40","slug":"clomipramine","status":"publish","type":"page","link":"https:\/\/www.ocduk.org\/overcoming-ocd\/medication\/clomipramine\/","title":{"rendered":"Clomipramine"},"content":{"rendered":"<p><b>(Brand Name: Anafranil)<\/b><\/p>\n<p class=\"caption\">The following information is a guide only and you must discuss your medication needs with a trained health professional.<\/p>\n<p>Clomipramine was first discovered in 1964 by the Swiss drug manufacturer Ciba-Geigyr and was the first drug that was investigated for and found to be effective in the treatment of OCD. The effectiveness of clomipramine in the treatment of OCD is far greater than that of other Tricyclic antidepressants (TCAs) and is the only non SSRI that the NICE guidelines recommend outside of SSRI medications.<\/p>\n<h5>Key Facts:<\/h5>\n<ul>\n<li>Clomipramine can cause withdrawal symptoms so don&#8217;t stop taking it without talking to your doctor<\/li>\n<li>Check with your doctor before starting to take Clomipramine if you are trying to become pregnant, or plan to discontinue it if you&#8217;re already pregnant or you are breastfeeding<\/li>\n<\/ul>\n<div id=\"x-content-band-1\" class=\"x-content-band border-top border-left border-right border-bottom\" style=\"background-color: #eeeeee;\"><div class=\"x-container\"> <div  class=\"x-container max width\" > <h4  class=\"h-custom-headline center-text accent\" style=\"margin: 1.25em;\"><span>Medication Information<\/span><\/h4>\n<div id=\"attachment_2736\" style=\"width: 310px\" class=\"wp-caption alignright\"><a href=\"\/wp-content\/uploads\/2018\/05\/Clomipramine.svg_.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-2736\" class=\"size-medium wp-image-2736\" src=\"\/wp-content\/uploads\/2018\/05\/Clomipramine.svg_-300x274.png\" alt=\"Skeletal formula of clomipramine\" width=\"300\" height=\"274\" srcset=\"https:\/\/www.ocduk.org\/wp-content\/uploads\/2018\/05\/Clomipramine.svg_-300x274.png 300w, https:\/\/www.ocduk.org\/wp-content\/uploads\/2018\/05\/Clomipramine.svg_-100x91.png 100w, https:\/\/www.ocduk.org\/wp-content\/uploads\/2018\/05\/Clomipramine.svg_-600x548.png 600w, https:\/\/www.ocduk.org\/wp-content\/uploads\/2018\/05\/Clomipramine.svg_.png 705w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><p id=\"caption-attachment-2736\" class=\"wp-caption-text\">Skeletal formula of Clomipramine<\/p><\/div>\n<p><b>The following information is a guide only, a doctor may want to try dosages outside these recommended guides.<\/b><\/p>\n<p><b>When: <\/b>Usually at bedtime.<\/p>\n<p><b>Child dose: <\/b>Not recommended.<\/p>\n<p><b> Adult dose<\/b>: The initial dose for adults is 25mg daily, as a single dose,\u00a0 however, it may be started at a lower dose and increased gradually over 2 weeks to 100\u2013150\u202fmg and up to a maximum of 250\u202fmg per day.<\/p>\n<p><b>Older people<\/b>: The initial dose for older adults is 10mg daily, as a single dose,\u00a0 however, it may be started at a lower dose and gradually increased gradually over 2 weeks to 100\u2013150\u202fmg and up to a maximum of 250\u202fmg per day.<\/p>\n<a  class=\"x-extra\" data-x-element=\"extra\" data-x-params=\"{&quot;type&quot;:&quot;popover&quot;,&quot;trigger&quot;:&quot;hover&quot;,&quot;placement&quot;:&quot;top&quot;,&quot;title&quot;:&quot;title=\\&quot;What is Half-Life?\\&quot;&quot;,&quot;content&quot;:&quot;Every medication has a certain amount of time that it remains active before the body begins to metabolise or excrete it. More simply put, the half-life of a drug is how long it takes for half of it to be eliminated from the bloodstream. This depends on how the body processes and gets rid of the drug, and can vary from a few hours to a few days for some medications. A drug\\u2019s half-life matters because a short half-life usually means more withdrawal problems compared to  a long half-life. So all SSRIs should be withdrawn slowly and under the supervision of your prescribing doctor.&quot;}\"  href=\"#\" title=\"What is Half-Life?\" ><strong>Half-Life:<\/strong><\/a>\u00a019-37 hours.<\/p>\n<p>The NICE guidelines, published in November 2005, reported that Clomipramine should be considered in the treatment of adults with OCD or BDD after an adequate trial of at least one SSRI has been ineffective or poorly tolerated, or if the patient prefers Clomipramine or has had success in using the medication before.<\/p>\n<p><b>Pregnancy and Breast Feeding<\/b>:  It&#8217;s important for you and your baby that you stay well during your pregnancy. If you become pregnant while taking Clomipramine speak to your doctor, it&#8217;s important not to stop taking your medicine unless your doctor tells you to.\u00a0 Ask your doctor to discuss the potential benefits against potential risks of staying on medication whilst pregnant or breastfeeding so that you can make an informed choice about what is right for you and your baby.\u00a0  <\/p>\n<\/div> <\/div><\/div>\n<p>&nbsp;<\/p>\n<p class=\"titleh5\">What to read next:<\/p>\n<div class=\"x-column x-sm x-1-2\"><span class=\"alignleft\"> <a style=\"outline: none;\" title=\"Back to Medication for OCD\" href=\"\/overcoming-ocd\/medication\/\"><i class=\"x-icon x-icon-arrow-left\" data-x-icon=\"\uf060\" aria-hidden=\"true\"><\/i> Medication for OCD<\/a><\/span><\/div>\n<hr class=\"x-clear\" \/>\n<hr  class=\"x-gap\" style=\"margin: 20px 0 0 0;\">\n<div id=\"pi-accordion\" class=\"x-accordion\" > <div  class=\"x-accordion-group\" ><div class=\"x-accordion-heading\"><a id=\"tab-6940ec701f0cb\" class=\"x-accordion-toggle collapsed\" role=\"tab\" data-x-toggle=\"collapse-b\" data-x-toggleable=\"6940ec701f0cb\" data-x-toggle-group=\"pi-accordion\" aria-selected=\"false\" aria-expanded=\"false\" aria-controls=\"panel-6940ec701f0cb\"><i class='x-framework-icon x-shortcode-accordion-icon' data-x-icon-s='&#x2b;' aria-hidden=true><\/i><span>Page information and additional reading<\/span><\/a><\/div><div id=\"panel-6940ec701f0cb\" class=\"x-accordion-body x-collapsed\" role=\"tabpanel\" data-x-toggle-collapse=\"1\" data-x-toggleable=\"6940ec701f0cb\" aria-hidden=\"true\" aria-labelledby=\"tab-6940ec701f0cb\"><div class=\"x-accordion-inner\">\n<div  class=\"x-container max width\" >\n<div  class=\"x-column x-sm x-1-2\" style=\"\" >[lastreviewed]<\/div>\n<div  class=\"x-column x-sm x-1-2 last\" style=\"\" > [nextreviewed] <\/div>\n<\/div>\n<hr  class=\"x-gap\" style=\"margin: 20px 0 0 0;\">\n<p class=\"p-medium\"><b>Additional Reading:<\/b><\/p>\n<ul>\n<li>\n<p class=\"p-medium\"><a href=\"https:\/\/bnf.nice.org.uk\/drug\/clomipramine-hydrochloride.html\" target=\"_blank\" rel=\"noopener\">NICE &#8211; Clomipramine <\/a><span class=\"p-small\">(External Website)<\/span><\/p>\n<\/li>\n<\/ul>\n<hr  class=\"x-gap\" style=\"margin: 20px 0 0 0;\">\n<p class=\"p-small\"><b>Disclaimer:<\/b> This article is for information only and should not be used for the diagnosis or treatment of Obsessive-Compulsive Disorder or any other medical condition. OCD-UK have taken all reasonable care in compiling this information, but always recommend consulting a doctor or other suitably qualified health professional for diagnosis and treatment of Obsessive-Compulsive Disorder or any other medical condition.\n<\/div><\/div><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>(Brand Name: Anafranil) The following information is a guide only and you must discuss your medication needs with a trained health professional. Clomipramine was first discovered in 1964 by the Swiss drug manufacturer Ciba-Geigyr and was the first drug that &#8230; <\/p>\n<div><a href=\"https:\/\/www.ocduk.org\/overcoming-ocd\/medication\/clomipramine\/\" class=\"more-link\">Read More<\/a><\/div>\n","protected":false},"author":1,"featured_media":0,"parent":2679,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2733","page","type-page","status-publish","hentry","no-post-thumbnail"],"_links":{"self":[{"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/pages\/2733","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/comments?post=2733"}],"version-history":[{"count":0,"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/pages\/2733\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/pages\/2679"}],"wp:attachment":[{"href":"https:\/\/www.ocduk.org\/wp-json\/wp\/v2\/media?parent=2733"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}